Merck Sharp + Dohme Corp.

Merck Sharp + Dohme B.v.

Schering Corporation

Irina Kazakevich

Tao Feng

Jim H Kou

Scott Trzaska

Sachin Mittal

Susan K Heimbecher

Luke R Schenck

Himanshu Bhattacharjee

Peter Bakker

Nazia Khawaja

David J Goldfarb

Amitava Mitra

Donna Carroll

The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

Formulation for parenteral administration

The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A&#x3b2; pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A&#x3b2; pathologies, including Alzheimer's disease, are disclosed herein.

Crystalline forms of a BACE inhibitor, compositions, and their use

Growing community of inventors

Rockaway, NJ, United States of America

Irina Kazakevich