Chanel Parfums Beaute

Centre National De La Recherche Scientifique

Université De Nice Sophia Antipolis

Irina Berlin

Gaelle Gendronneau

Francois Lejeune

Johannes Grillari

Serge Holderith

Emmanuelle Bouissou-Cadio

Gaëlle Gendronneau

Xavier Fernandez

François Lejeune

Anais Tromeur

Alexandre Casale

Ingo Lammermann

Julie Latreille

Florian Gruber

Marie-Sophie Narzt

Ingo LÄMMERMANN

The disclosure relates to the identification and the use of compounds which regulate the expression of at least one Sestrin gene, for preventing and/or attenuating skin ageing, and/or for hydrating the skin and/or for regulating skin pigmentation. The method includes the following steps: a. bringing at least one test compound in contact with a sample of human keratinocytes or melanocytes; b. measuring the expression of at least one Sestrin gene chosen from SESN3, SESN2 and SESN1 in the keratinocytes or melanocytes; c. selecting the compounds for which an activation of at least 1.6 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes, or for which a significant modulation of the expression of at least one of the genes is measured in the melanocytes treated in a. compared with the untreated melanocytes.

Sestrin activators for preventing and/or attenuating skin ageing and/or hydrating the skin and/or for regulating skin pigmentation

Disclosed are methods for screening for candidate compounds for hydrating the skin. The compounds selected according to the methods disclosed therein stimulate the intra-cellular amount and/or activity of TonEBP in keratinocytes. Preferably, the selected compounds induce a stimulation of at least 20%, preferably at least 50%, preferably at least 100% of the activity and/or intra-cellular amount of TonEBP.

Activators of TonEBP for use for hydrating skin

An alcoholic extract of aerial parts ofsubsp.the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

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Growing community of inventors

Vincennes, France

Irina Berlin