Merck Sharp + Dohme Corp.

Pfizer Corporation

Cornell University

Beth Israel Deaconess Medical Center, Inc.

Irina Apostolou

Paul D Ponath

Michael Rosenzweig

Joe Ponte

Lou Vaickus

Lioudmila Tchistiakova

Lidia Mosyak

Lewis C Cantley

Kimberly Ann Marquette

Isaac J Rondon

Eric M Bennett

Chao Bai Huang

Brooke M Emerling

Edward Christian Rosfjord

Georgios Poulogiannis

Hui Liu

Stephen P Soltoff

Cindy M Hodakoski

Brian Gaither Bates

Jose Ponte

The present disclosure provides materials and methods for CUB domain-containing protein 1 (CDCP1)-targeted therapy.

CDCP1 antibodies and antibody drug conjugates

Disclosed herein are antibodies and ILT5-binding fragments thereof that specifically bind to ILT5, e.g., human ILT5 (hILT5), and pharmaceutical compositions comprising such ILT5-binding antibodies and ILT5-binding fragments thereof.

Anti-ILT5 antibodies and ILT5-binding antibody fragments

Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as immunostimulatory adjuvants.

Immunoregulation by anti-ILT5 antibodies and ILT5-binding antibody fragments

Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to induce an immunostimulatory effect in a T cell when such a T cell is contacted with an antigen presenting cell (APC) that has been previously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof to inhibit a response in a T cell (e.g., a pro-liferative response) when such a T cell is concomitantly contacted, or has previously been contacted, with an APC, which APC is simultaneously contacted with the anti-ILT5 antibody or ILT5-binding fragment. Also disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as immunostimulatory adjuvants.

Growing community of inventors

Norwell, MA, United States of America

Irina Apostolou