The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Secretary of

Irina A Lubensky

Lance A Liotta

Zhengping Zhuang

Francis S Collins

Michael R Emmert-Buck

William G Stetler-Stevenson

Mark Roth

Allen M Spiegel

Pachiappan Manickam

Larisa V Debelenko

Sunita K Agarwal

A Lee Burns

Settara Chandrasekharappa

Stephen J Marx

Siradanahalli Guru

Michael R Buck

The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.

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A method of direct extraction of cellular material from a tissue sample which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extracted zone(s) of cells is subjected to analysis. The overall process of identifying, extracting, transporting, and analyzing the extracted zones(s) of cells can be fully automated.

Isolation of cellular material under microscopic visualization using an

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Silver Spring, MD, United States of America

Irina A Lubensky