Medtronic, Inc.

Irfan Z Ali

Earle Timothy Roberts

Keith Alan Miesel

David C Ullestad

Donald L Villalta

Scott L Kalpin

Scott A Sarkinen

Nathan Andrew Torgerson

Garrett R Sipple

David S Slack

Sudheendhar Raghavendran

Touby Austin Drew

William J Mitchell

Steven R Christenson

Prasanna Anbazhagan

Steven M Goetz

Bernard Q Li

Reginald D Robinson

Charles Randall Rogers

Nicholas R Whitehead

Ronald L Mezera

Jiaying Shen

Emem D Akpan

Cynthia R Nelson Konen

Mark Salzwedel

Mary E Robischon

Devices, systems, and techniques for programming drug delivery are described. Such techniques may account for diffusion and mixing of drug within the fluid or allow for more flexible programming options. In one example, a method may include determining one or more fluid delivery parameters (e.g., volume, flow rate, or period of time) for a fluid that is a mixture of two other fluids. The determination may be based on one or more fluid delivery parameters of the two other fluids and/or a concentration profile representing the mixing between the two other fluids. In other examples, drug delivery programming may be facilitated by the selection of various patterns and steps of drug delivery. The system may track volume of delivered fluid to maintain desired dosing of the patient.

Drug delivery programming techniques

A total dose of a therapeutic agent to be delivered to a patient by an infusion device over a total period of time is automatically divided into a plurality of unit doses to be delivered to the patient over a plurality of unit periods of time. The infusion device is automatically programmed to deliver one of the unit doses of the therapeutic agent to the patient over its respective unit period of time, after which the one unit dose is delivered, and a determination is made of whether an error occurred in delivering the one unit dose to the patient. Delivery of the total dose of the therapeutic agent to the patient may include iteratively automatically programming the infusion device to deliver successive unit doses upon determining that no error occurred in delivering a previous unit dose to the patient. Accordingly, the risk of improperly dosing the patient with the therapeutic agent in an event of a software or hardware anomaly within the infusion device is prevented or reduced.

Detecting and responding to software and hardware anomalies in a fluid delivery system

A method includes receiving data regarding a catheter being used with the infusion device. The catheter has a lumen operably coupled to a reservoir of the infusion device and is configured to deliver fluid from the infusion device to a target location of a patient. The method further includes infusing fluid from the reservoir into the lumen of the catheter at a first rate and monitoring pressure via a pressure sensor in communication with the lumen of the catheter. Monitoring the pressure includes acquiring pressure data from the pressure sensor at a first frequency. The method also includes (i) determining whether the monitored pressure exceeds a first threshold, wherein the first threshold is based on the data regarding the catheter; and (ii) decreasing the rate at which the fluid is delivered from the reservoir into the catheter if the monitored pressure is determined to exceed the threshold.

Limiting pressure in an implanted catheter

A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the valve to open and close the first fluid pathway and to open and close the second fluid pathway.

Drug infusion device with controllable valve

Unexpected changes in the volume of therapeutic fluid in the reservoir of a fluid delivery device are detected based on changes in the pressure of the reservoir measured over a period of time by a pressure sensor. Additionally, an ambulatory reservoir fluid volume gauge is provided to indicate an actual volume of therapeutic fluid in a fluid delivery device reservoir. The actual volume of therapeutic fluid in the reservoir indicated by the ambulatory reservoir fluid volume gauge is determined based on changes in the pressure in the reservoir measured over a period of time by a pressure sensor.

Volume monitoring for implantable fluid delivery devices

A method of detecting a fault condition within an implantable medical pump comprises delivering therapeutic fluid using a medical pump comprising an actuation mechanism configured to be energized to provide a pump stroke, detecting a property associated with energizing the actuation mechanism, and determining whether the property associated with energizing the actuation mechanism indicates that a fault condition exists with the medical pump.

Implantable medical pump diagnostics

Devices and systems provide for proximity based selection of an implantable medical device for far field communication with an external device. By using a proximity communication that is limited to the IMD of interest during the selection process, the external device can eliminate those IMDs that are in range of far field communications but are able to receive the proximity communication. Thus, information may be shared via a proximity communication that is validated via a far field communication, or shared via a far field communication as a challenge and then validated via a proximity communication. The proximity communication may be used to initially limit the number of devices that respond to a discovery request and then subsequently used to select the intended implantable medical device as well as automatically select the appropriate therapy application corresponding to the selected IMD.

Proximity based selection of an implantable medical device for far field communication

Methods, devices and systems are disclosed that provide for dynamically adjusting the valid lifespan of a session key for wireless communication sessions established between at least two medical devices. Adjusting the session key lifetime balances protecting the communications link so that it is not unnecessarily susceptible to eavesdropping by third parties or other interference while obviating the need for a user to repeatedly perform access control steps.

Adaptively configuring the validation timeout of a session key used for securing communication with an implantable medical device

A medical device system comprises a reservoir configured to store a therapeutic fluid and a medical pump configured to deliver the therapeutic fluid from the reservoir to a patient. The system also comprises a sensor that can detect a characteristic associated with the pump and a processor to determine if the characteristic detected indicates the reservoir is empty or near empty. The characteristic may comprise a characteristic of a noise made by an actuator within the pump at the end of a pump stroke.

Detecting empty medical pump reservoir

A fluid delivery system comprises a pump configured to deliver a therapeutic agent to a patient, a memory storing a therapy program defining the delivery of the therapeutic agent to the patient by the pump and a default infusion schedule based on the therapy program, and a processor configured to control the pump to deliver the therapeutic agent to the patient according to the therapy program, to determine an error condition that prevents the pump from continuing to deliver therapy according to the therapy program, and, upon determination of the error condition, to control the pump to deliver the therapeutic agent to the patient according to the default infusion schedule.

System and method for delivering a therapeutic agent according to default infusion schedule

Drug infusion system capable of delivering a fluid medication to a patient and method for doing same is described. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.

Drug infusion system and method adapted to start during programming cycle

A system including an implantable delivery device having a housing, a reservoir, fill and catheter access ports, and a denial device. The housing maintains the fill port in fluid communication with the reservoir. The catheter access port includes a septum between an inlet and a well. The denial device includes a pin, a biasing element, and a solenoid. The pin is arranged to be movable between a first position in which the pin blocks passage of a needle into the well and a second position, with the biasing element biasing the pin to the first position. The solenoid is operatively coupled to the pin and provides an energized and de-energized states; in the energized state, the solenoid moves the pin from the first position to the second position to permit access to the well. An external controller effectuating clinician control over operation of the denial device is also provided.

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Woodbury, MN, United States of America

Irfan Z Ali