Nevakar Inc.

Vyluma Inc.

Nevakar Injectables Inc.

Irfan A Mohammed

Kumaresh Soppimath

Prem Sagar Akasapu

Iouri V Ilitchev

Navneet Puri

Tushar Hingorani

Tao Zhang

The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.

Atropine pharmaceutical compositions

Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.

Ephedrine compositions and methods

Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25&#xb0; C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.

Atropine Pharmaceutical Compositions

Growing community of inventors

Cherry Hill, NJ, United States of America

Irfan A Mohammed