Vertex Pharmaceuticals, Inc.

Nanosystems L.l.c.

Sterling Winthrop Inc.

Irennegbe K Osifo

Roland Ellwood Dolle

Joseph M Salvino

Prasad V Chaturvedula

Catherine P Prouty

Tina Morgan Ross

James M Rinker

Jasbir Singh

Stanley J Schmidt

Denton W Hoyer

Mark A Ator

Eric P Lodge

Carl R Illig

Edward R Bacon

Matthew S Miller

Mohamed M Awad

Todd L Graybill

Mohamed M A Awad

Thomas S Caulfield

Alex L Harris

Jill S Gregory

Disclosed are compounds, compositions, and methods for inhibiting interleukin-1&bgr; protease activity, wherein the compounds are &agr;-substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1&bgr; converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.

Peptide analogs as irreversible interleukin-1&bgr; protease inhibitors

Disclosed are compounds, compositions and methods for inhi.beta.iting interleukin-1.beta. protease activity, the compounds .alpha.-substituted methyl ketones having the formula (I) set forth herein. These compounds are inhibitors of IL-1.beta. converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.

Peptide analogs as irreversible interleukin-1.beta. protease inhibitors

A compound of the formula ##STR1## wherein: Z is aryl, substituted aryl, phenyl-lower-alkyl, hetero-aryl, substituted heteroaryl, heterocycloalkyl, heterocyclocalkyl-lower-alkyl, hetero-aryl-lower-alkyl wherein one or more hydrogens of aryl and heteroaryl is optionally replaced by A and B;

Quinolone carboxamide Calpain inhibitors

This invention relates to methods of x-ray diagnostic imaging the blood pool and/or lymph system of a mammal comprising administering a contrast effective amount of a particulate iodinated aroyloxy ester contrast agent having the structure: ##STR1## wherein n is an integer from 3 to 20; R.sup.1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;

Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for

This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: R is alkyl having from 1 to 20 carbon atoms, aryl having from 6 to 11 carbon atoms, or R.sup.1 CO.sub.2 R.sup.2 and

Nanoparticulate iodipamide derivatives for use as x-ray contrast agents

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W. Norriton, PA, United States of America

Irennegbe K Osifo