Commonwealth Scientific and Industrial Research Organisation

Grains Research and Development Corporation

Irene Horne

Surinder Pal Singh

Xue-Rong Zhou

Allan Graham Green

Craig Christopher Wood

John Graham Oakeshott

Robyn Joyce Russell

Tara Sutherland

Victoria Shirley Haritos

Katherine Damcevski

Karen Glover

Rebecca Harcourt

Stephen Charles Trowell

Helen Dacres

Virginia Leitch

The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.

Synthesis of fatty acids

The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at least one G protein coupled receptor embedded in a lipid Mayer which when expressed in a cell the N-terminus of the G protein coupled receptor, or subunits thereof, is outside the cell and the C-terminus is inside the cell, and which is capable of binding the compound. Optionally, the composition also comprises at least one accessory molecule that directly or indirectly binds an intracellular loop and/or the C-terminus of the G protein coupled receptor. The G protein coupled receptor, and/or accessory molecule when present, in combination comprise a bioluminescent protein and an acceptor molecule, which enables bioluminescent resonance energy transfer (BRET) to be used to detect the compound binding the receptor.

Measuring G protein coupled receptor activation

The present invention provides enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention provides a phosphotriesterase enzyme identified from anstrain isolated from soil that hydrolyses OP pesticides, and the gene encoding that enzyme. The invention also provides mutants of the identified phosphotriesterase enzyme which have altered substrate specificity. The use of these enzymes in bioremediation strategies is also provided.

Phosphotriesterase from agrobacterium radiobacter P230

Phosphotriesterase from agrobacterium radiobacter p230

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Yass, Australia

Irene Horne