Egis Gyogyszergyar

Muanyagipari Kutato Intezet

Iren Barta

Gabor Kovacs

Pal Fekete

Laszlo Pallos

Lajos Mahr

The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 .mu.m with a high-energy irradiation in a dose of 1-15 Mrad--preferably with electrone radiation--and thereafter stretched at 80.degree.-90.degree. C. to a thickness of 2-200 .mu.m. The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.

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Budapest, Hungary

Iren Barta