Becton Dickinson and Company Limited

The General Hospital Corporation

The Charles Stark Draper Laboratory, Inc.

University of Texas System

Wenco LLC

Toyota Research Institute, Inc.

Biogen Ma Inc.

Embecta Corp.

Ira Spool

Michel Bruehwiler

Ryan Everett Schoonmaker

Melissa Rosen

Jeffrey T Borenstein

Cole Constantineau

Joseph P Vacanti

David M Hoganson

Sean Sullivan

Abhijitsinh S Raj

Howard I Pryor

Sean P Sullivan

Eric P Chan

Seth O Newburg

Firas Mourtada

Wendy L Silver

Michael I Silver

Rama Chorpash

Anuja Jhingran

Patricia Eifel

John Horton

Guy Danner

Ara N Knaian

John William Hoppin

Aimee S Goncalves

Erik C Sobel

Ajay Verma

Joseph Fenton

Calder Phillips-Grafflin

Elliot Greenblatt

Rachel M Chaney

Nicholas Brennan

Guy M Danner

Jonathan Kalow

Abhijitsin S Raj

Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.

Medical diagnostic and treatment systems and their methods of use

An assembly for storing both new and used pen needles of an injection apparatus, comprising a plurality of storage units each configured to store a pen needle having a needle fixed to a hub, the plurality of storage units being hingedly connected, and each including a storage end, and a dispensing end having an anti-rotation structure, wherein the anti-rotation structure working in conjunction with the hub of the pen needle to prevent rotation of the pen needle when the pen needle is in a dispensing position.

Method of storing both new and used pen needles

The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

Biomimetic vascular network and devices using the same

A robotic grommet installer includes a robotic arm and an installation unit. The installation unit includes a rotary grommet holder rotatively coupled to the robotic arm and an installer coupled to the robotic arm. The rotary grommet holder includes a plurality of grommet chambers spaced circumferentially about a rotational axis of the rotary grommet holder. Each grommet chamber of the plurality of grommet chambers is configured to hold a plurality of grommets. The installer is configured to retrieve a grommet from the rotary grommet holder, wherein the rotary grommet holder is configured to rotate to align the installer with an available grommet positioned within one of the plurality of grommet chambers.

Robotic grommet installers and methods of installing grommets

A dual-chambered drug delivery device, comprising a cartridge having a first chamber for storing a medicament, a second chamber in fluid communication with said first chamber, a dose setting member for setting a medicament dose to be injected at an injection site, a piston disposed in said second chamber, an upward stroke of said piston drawing a portion of the medicament dose into said second chamber and a downward stroke of said piston expelling the portion of the medicament dose, a needle communicating with said second chamber for sequentially injecting portions of the medicament dose into the injection site, a drive screw movably connected to said dose setting member such that rotation of said dose setting member moves said drive screw upwardly, and a rack movably connected to said drive screw such that downward movement of said drive screw during the medicament dose injection rotates said rack.

Multi-stroke delivery pumping mechanism for a drug delivery device for high pressure injections

A method of delivering high pressure medication injections, the method comprising storing a medicament in a cartridge, engaging a lever gear in a lever assembly to a rack, rotating a lever arm in said lever assembly that is connected to said lever gear, moving said rack to move a stopper through said cartridge upon rotation of said lever arm, expelling a medicament dose from said cartridge via movement of said stopper, and injecting said medicament dose through a needle that communicates with said cartridge.

Lever and gear force multiplier medication delivery system for high pressure injection system

A flip-open multi-pack assembly which contains a plurality of new pen needles via a rectangular or tube-shaped, hinged shell housing, wherein new pen needles are stored in a plurality of user accessible openings each having a sterility barrier formed by covers that cover the non-patient end of the openings where the new pen needles are contained. Used pen needles are returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell include a slidable internal holder configured to releasably secure the inner shield of the new pen needle, and subsequently be pulled forward when the new pen needle is removed and locked at a forward position, to create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.

A drug delivery device includes a cartridge () for storing a medicament and a needle () communicating with the cartridge () for injecting a medicament dose. A rack () is movably disposed in the cartridge () and is engageable with a stopper () for expelling the medicament dose from the cartridge (). A lever assembly () has a lever arm () connected to a lever gear (). The lever gear () is engaged with the rack () such that rotation of the lever arm () rotates the lever gear () during injection of the medicament dose, thereby moving the rack () and stopper () through the cartridge () to deliver the medicament dose.

A dual-chambered drug delivery device () includes a first chamber () in which a medicament is stored. A dose setting member () is rotated to set a medicament dose. The dose setting member () being rotatable to set the medicament dose. The dose setting member () is not axially moveable. A second chamber () is in fluid communication with the first chamber (). The medicament dose is transferred to the second chamber () from the first chamber () prior to injecting the medicament dose. A needle () communicates with the second chamber () to inject the medicament dose into an injection site.

Dual-chambered drug delivery device for high pressure injections

A dual-chambered drug delivery device () includes a cartridge () having a first chamber () for storing a medicament and a second chamber () in fluid communication with the first chamber (). A dose setting member () is used to set a medicament dose to be injected at an injection site. A piston () is disposed in the second chamber (). An upward stroke of the piston () draw a portion of the medicament dose into the second chamber () and a downward stroke of the piston () expels the portion of the medicament dose. A needle () communicates with the second chamber () for sequentially injecting the portions of the medicament dose into the injection site.

A dual-chambered drug delivery device () includes a first chamber () in which medicament is stored and a second chamber () in fluid communication with the first chamber (). A medicament dose is transferred to the second chamber () from the first chamber () prior to injecting the medicament dose. A needle () communicates with the second chamber () for injecting the medicament dose into an injection site.

Open and closed valve medication delivery system for high pressure injections

A flip-open multi-pack assembly is provided which can contain a plurality of new pen needles, such as through the provision of a rectangular or tube-shaped shaped, hinged shell housing, wherein new pen needles can be stored in a plurality of user accessible openings each having a sterility barrier formed, for example, by covers that cover the non-patient end of the openings in which the new pen needles are contained. Used pen needles can be returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell can be provided with a slidable internal holder within the device and are configured to releasably secure the inner shield of the new pen needle, and to then be pulled forward when the new pen needle is removed and lock at a forward position, and thereby create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.

Needle dispensing and storing apparatus for medicament delivery device

The invention is a novel adaptive CT-friendly brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.

Adaptive intracavitary brachytherapy applicator

Growing community of inventors

Newton, MA, United States of America

Ira Spool