Genentech, Inc.

Yale University

F. Hoffmann-la Roche Ag

Ira Mellman

Tarek M Fahmy

Michael J Caplan

William Mark Saltzman

Mahesh Yadav

Jennie Lill

Lelia Delamarre

Suchit Jhunjhunwala

The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

Identification of immunogenic mutant peptides using genomic, transcriptomic and proteomic information

Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.

Modular nanodevices for smart adaptable vaccines

Modular nanoparticles for adaptable vaccines

Growing community of inventors

San Francisco, CA, United States of America

Ira Mellman