Otsuka Pharmaceutical Factory, Inc.

Adabio Co., Ltd.

Jnc Corporation

Ippei Yamaoka

Katsuya Hiraishi

Taro Adachi

Fumie Jimma

Hiroyuki Soma

Masakazu Adachi

Tomohiro Kagawa

Takaya Sato

Naoyuki Yoshida

Masako Doi

Yasuhiro Mitsumoto

Kazushi Ishida

Shuji Sasaki

Naoyuki Endo

Hideaki Kohri

Masaru Kobayashi

Kozo Asagi

Tutomu Uehara

Tetsuya Fukunaga

Mitsuo Nakayama

By using ion exchange column chromatography or calcium carbonate to an aqueous solution containing a compound A represented by the following formula and citric acid, citric acid in the aqueous solution is removed and a crystalline compound A is obtained by being thereafter subjected to several steps. Further a high-purity noncrystalline compound A is obtained by using calcium carbonate, sulfuric acid, an organic solvent and the like to the aqueous solution containing the compound A and citric acid to remove citric acid and the crystalline compound A in the solution. The configuration of the crystalline compound A is an SS isomer in the RS notation system. The configuration of the noncrystalline compound A is an SR isomer. 

Method for manufacturing diastereomer of citric acid derivative

Compounds (citric acid derivatives) represented by formulas (1) and (2) below are novel compounds having an inhibitory effect against liver disorder and can be used as liver disorder inhibitors and food additives (wherein Rrepresents a C1 to C3 alkyl group optionally having a carboxyl group or a hydroxyl group, and Rrepresents a hydrogen atom, or Rand Roptionally form a cyclic structure together to represent a C2 to C3 alkylene chain). 

Citric acid derivative

The present invention provides a prophylactic and/or therapeutic agent for non-alcoholic fatty liver disease (NAFLD), and particularly non-alcoholic steatohepatitis (NASH) comprising an ume (Japanese apricot) juice concentrate or a processed product thereof. The prophylactic and/or therapeutic agent is obtained by utilizing a component contained in a plant or a processed product thereof, and hence is safe and easily taken. It has been confirmed that when the ume juice concentrate or the processed product thereof is orally administered to a streptozocin (STZ)-induced NAFLD model mouse or an STZ-induced NASH model mouse, liver fibrogenesis can be reduced.

Prophylactic and/or therapeutic agent for NAFLD/NASH

The invention provides a metal salt of a crosslinked cellulose derivative represented by the following formula (I), wherein the degree of substitution of the hydroxyl group of glucose unit of the crosslinked cellulose derivative by a functional group a is 1 or more.R&#x2014;O&#x2014;A&#x2003;&#x2003;(I){In the formula (I), R represents a crosslinked cellulose residue and A represents a functional group a having cation-exchange ability.}

Metal salt of crosslinked cellulose derivative

An inhibitor for perioperative blood sugar elevation characterized by containing a branched amino acid, a compound which can be converted into a branched amino acid in vivo or a compound to which an amino group has been transferred from a branched amino acid. This inhibitor for perioperative blood sugar elevation is useful as a drug which is safe to the living body including human, inhibits abnormal elevation in the blood glucose level caused by anesthesia, surgery, etc., and enables proper blood sugar control, when administered to a perioperative patient.

Inhibitor for perioperative blood sugar elevation

An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal salt (excluding sodium salt) of lambda-carrageenan as an active ingredient, can excrete excessively ingested common salt outside the body positively and safely, and particularly have excellent action in excreting the sodium ions into feces.

Sodium ion absorption inhibitors, sodium ion excretion accelerators, and preventive and therapeutic agents for diseases resulting from excessive intake of common salt

Growing community of inventors

Tokushima, Japan

Ippei Yamaoka