Societe Leb-Tech

Agence Nationale De Valorisation De La Recherche (Anvar)

Medisup International, N.v.

Ion Gresser

Georges Lutfalla

Knud Erik Mogensen

Gilles Uze

Michael Gerard Tovey

Francois Meyer

Pierre Eid

Water-soluble polypeptides having high affinity for interferons &agr; and &bgr;; DNA sequences and expression cells; a preparation method therefor; drugs; compositions containing same; and uses thereof as a diagnostic agent or for producing antibodies.

Water-soluble polypeptides having a high affinity for &agr; and &bgr; interferons

The subject invention relates to a purified receptor of human alpha interferon.

Purified human alpha interferon receptor

The present invention relates to antibodies against an alpha interferon receptor, as well as to kits comprising such antibodies. The antibodies of the invention are suitable for the assay of the receptors or for their visualization in the case of imaging. The present antibodies and kits can thus be used as diagnostics or imaging agents, or as pharmacological models to test compounds derived from human alpha interferon.

Antibodies directed against the alpha interferon receptor

The invention relates to the use of the human alpha interferon receptor and of non human host cells which express said receptor, to identify alpha interferon agonists.

Use of the alpha interferon receptor and cells which express the

The invention relates to the human alpha interferon receptor and to the DNA sequence, including the cDNA sequence, encoding the receptor. The invention also relates to non-human cells which express said receptor, to a process for obtaining said cells, and to a process for the preparation of the receptor.

cDNA fragment coding the alpha interferon receptor gene and process for

This invention relates to the production of interferon. In accordance with the present invention, interferon is produced by growing a continuous cell line in a suspension culture, the cells first being primed by cultivation in the presence of interferon specific to the cells and L-glutamine, interferon production being initiated by contacting the cells with a high concentrated suspension of virus inducer, then removing the virus and incubating the cells in a nutrient medium. Concentration and purification to give interferon preparations can be effected by known methods. Various types of interferon preparations of high titre have been produced on an industrial scale.

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Paris, France

Ion Gresser