Glycom A/s

Ioannis Vrasidas

Gyula Dekany

Markus Jondelius Hederos

Markus Hederos

Christoph Röhrig

Lars Kröger

Andreas Schroven

Julien Boutet

Piroska Kovács-Pénzes

Christian Risinger

Ferenc Horváth

Károly Ágoston

Ágnes Ágoston

István Bajza

Gergely Pipa

Sándor Demkó

Ignacio Pérez Figueroa

Péter Trinka

Johan Olsson

Gyula Dékany

László Kalmár

Istvan Bajza

Ignacio Figueroa Pérez

Elise Champion

Marie Bøjstrup

Mette Fanefjord

Ignacio Figuero-Pérez

Ågnes Jánosi

Irme Kovács

Ágnes Jànosi

Ferenc Horvàth

Krisztián Kovàcs

Sándor Demkò

Gábor Kádár

Ignacio Figueroa-Pérez

Imre Kovács

Gyula DÉKANY

The present invention relates to a method for preparation of the trisaccharide 6'-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6&#x2032;-O-sialyllactose salts in pharmaceutical or nutritional compositions. 

Production of 6'-O-sialyllactose and intermediates

A compound of the formula (1) wherein Ris a group removable by hydrogenolysis, and wherein Ris OH or Ris &#x2014;NHRwherein Ris a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make free D-mannosamine or its salts, D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, N-acetyl-D-mannosamine and its hydrates and solvates, neuraminic acid derivatives, and viral neuraminidase inhibitors.

N-substituted mannosamine derivatives, process for their preparation and their use

The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an &#x3b1;-sialyl moiety and the other is H, Xrepresents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, Ris a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

Synthesis of sialooligosaccharide derivatives

The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates. 

Method for the synthesis of a trisaccharide

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. 

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates. 

The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.

Method for crystallization of fucose

The present invention relates to novel polymorphs of the trisaccharide 2'-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions. 

Polymorphs of 2'-O-fucosyllactose and producing thereof

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Thessaloniki, Greece

Ioannis Vrasidas