Accurate Polymers, Ltd.

Other

Loyola University of Chicago

Ioannis Scarpa

Bozidar Stipanovic

Martin John Griffin

Anita Beavins

Anita M Beavins

A method and compound for the purification of proteins including the attachment of a non-peptidic, small compound which simulates the affinity of Protein A for immumoglobulins to a support matrix. Once attached on the support matrix, the resulting monochloro-triazine derivative is reacted with an excess of an amino compound at a higher temperature to achieve high levels of substitution. The resulting support matrix with ligand is useful in the affinity separations of antibodies. Further, a mercapto heterocyclic system ligand may be attached to the super matrix and useful in affinity separations of antibodies.

Simulated activity of Protein A displayed by ligands attached to a cellulose bead surface

Disclosed are small particles of cellulose which are useful for liquid chromatography supports, and the like. Disclosed are methods for making small, substantially spherical bodies with a near complete absence of irregularities, holes, cracks, and the like. This is made possible by a new process wherein the coagulation of viscose is carried out before any regeneration is allowed to begin. This method is of general utility applying also to the production of rayon fiber and cellophane film.

Non-shrinking, non-swelling, cellulose bodies for chromatography

Cellulose chromatography support

Growing community of inventors

Chicago, IL, United States of America

Ioannis Scarpa