Korea Research Institute of Bioscience and Biotechnology

Snu Rdb Foundation

InPyo Choi

Hye Jin Kim

Kyung Seop Ahn

Jae Wha Kim

Sei-Ryang Oh

Doo Young Kim

Jung Hee Kim

Jung Weon Lee

Jae Sung Song

Hyeong-Kyu Lee

Sang Jick Kim

Se Mi Kim

HyeMi Ahn

JiHye Ryu

Ho-Bum Kang

Jin Myeong Song

Hye Jin Min

The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 L six family member 5 (TM4SF5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human TM4SF5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating liver fibrosis using the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody.

Monoclonal antibody which is specifically bound to TM4SF5 protein and use thereof

The present invention relates to an antiviral composition containing anorextract or a fraction thereof as an active ingredient. In detail, extracts oforor fractions thereof can induce the secretion of an immune-related cytokine, interferon-&#x3b3; (IFN-&#x3b3;) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.

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Daejeon, South Korea

InPyo Choi