Trilink Biotechnologies, Inc.

Inna Koukhareva

Alexandre Lebedev

Alexandre V Lebedev

Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3'-substituted nucleoside 5&#x2032;-triphosphates or 3&#x2032;-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods are accomplished by use of 3&#x2032;-substituted NTPs and/or 3&#x2032;-substituted terminated primers which provide utility in nucleic acid replication. In preferred embodiments, the NTPs and/or primers are substituted at the 3&#x2032;-position with particular heat labile chemical groups such as ethers, esters or carbonate esters.

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San Diego, CA, United States of America

Inna Koukhareva