Korea Research Institute of Chemical Technology

Inji Shin

Hwan Mook Kim

Kwangho Lee

Hwan Oh Kim

Gildon Choi

Chong Hak Chae

Byoung Chul Cho

Chae Won Park

Myoung Eun Jung

Krishna Babu Duggirala

Hyeon Jeong Choe

Byeong Uk Jeon

The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.

N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer

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Daejeon, South Korea

Inji Shin