Fred Hutchinson Cancer Center

Ingunn M Stromnes

Philip D Greenberg

Thomas M Schmitt

Aude Georgiana Chapuis

Rachel Perret

Tijana Martinov

The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.

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Kenmore, WA, United States of America

Ingunn M Stromnes