Wyeth

Pfizer Corporation

University of Minnesota

Ingrid Lea Scully

Annaliesa Sybil Anderson

Kathrin Ute Jansen

Mark Edward Ruppen

Bruce Arthur Green

Viliam Pavliak

Jasdeep Singh Nanra

Steven Morris Baker

Ellen Murphy

Yekaterina Timofeyeva

Jianxin Gu

Avvari Krishna Prasad

Jin-Hwan Kim

Rajesh Kumar Kainthan

Robert G K Donald

Paul A Liberator

Amardeep Singh Bhupender Bhalla

Lakshmi Khandke

A Krishna Prasad

Cindy Xudong Yang

Suddham Singh

Tracy Dee Scott

Stephen John Freese

Paul Patrick Cleary

Michael Hagen

Stephen Bruce Olmsted

The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from, commonly referred to as group B(GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

Group Bpolysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof

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The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

A number of &#x3b2;-hemolytic streptococci polynucleotides and polypeptides, particularlypolypeptides and polynucleotides, are described. Two or more of the polypeptides of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing infection caused by &#x3b2;-hemolytic streptococci.

Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease

The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from. The present invention also relates to immunogenic compositions, comprisingcapsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects againstusing immunogenic compositions of thepolypeptides and capsule polysaccharides.

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Cornwall, NY, United States of America

Ingrid Lea Scully