Deutsches Krebsforschungszentrum

Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Ingrid Grummt

Friedrich Grummt

Martin Vingron

The present invention relates to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, whose concentration and/or activity are correlated with the cell proliferation rate, and to DNA sequences encoding these proteins. The present invention also concerns ligands binding to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, respectively, antagonists as well as antisense RNAs and/or ribozymes, directed against the TIF-IA expression. These compounds are of use for the prevention or treatment of diseases associated with an increased or reduced cell proliferation.

RNA polymerase I transcription factor TIF-IA

The present invention relates to an expression vector having a foreign DNA. Said DNA at its 3&prime; end has a sequence which prevents the replication of the expression vector from occurring in the opposite direction to the transcription thereof. The invention also relates to a preparation containing such an expression vector and to the use of both in the permanent expression of foreign DNA in cells.

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Heidelberg, Germany

Ingrid Grummt