Incyte Pharmaceuticals, Inc.

Incyte Corporation

Incyte Genomics, Inc.

Ingrid E Akerblom

Janice K Au-Young

Jennifer L Hillman

Olga Bandman

Neil C Corley

Preeti G Lal

Karl J Guegler

Y Tom Tang

Henry Yue

Mariah R Baughn

Chandra S Arvizu

Roopa M Reddy

Jeffrey J Seilhamer

Timothy J Maslyn

Gina A Gorgone Simone

Tod M Klingler

Richard D Goold

Harold H Hibbert

Jennifer L Jackson

Rachel J Cheng

Yuanhua T Tang

Purvi Shah

Lynn E Murry

Christina M Altus

Surya K Goli

Phillip R Hawkins

Roger T Coleman

Frank D Russo

Gina A Gorgone

Angelo M Delegeane

Scott R Panzer

A Donny Strosberg

David M Hodgson

Laura Y Ito

Brian M McKelligon

Steve E Lincoln

Wendy B Levine

Samuel T LaBrie

Richard Cathcart

Andrew D Ament

Bernard Bailleul

Stephen E Lincoln

Landes C Wong

Helen E Jolley

Mayank K Thanawala

The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.

Methods for detecting expression levels of human signal peptide-containing proteins (HSPP)

Methods for treating colon cancer and inflammation associated with overexpression of human signal peptide-containing proteins

Antibodies which bind to signal peptide-containing molecules

Compositions comprising signal peptide-containing proteins

Polynucleotides encoding signal peptide-containing molecules

The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBPH and a method for producing EBPH. The invention also provides for use of EBPH and agonists, antibodies or antagonists specifically binding EBPH, in the prevention and treatment of diseases associated with expression of EBPH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding EBPH for the treatment of diseases associated with the expression of EBPH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding EBPH.

Antibody that binds human eosinophil-derived basic protein

Human eosinophil-derived basic protein

The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.

Relational database and system for storing information relating to biomolecular sequences and reagents

Polynucleotides encoding human eosinophil-derived basic protein

Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to association with one or more projects for obtaining full-length biomolecular sequences from shorter sequences. The relational database has sequence records containing information identifying one or more projects to which each of the sequence records belong. Each project groups together one or more biomolecular sequences generated during work to obtain a full-length gene sequence from a shorter sequence. The computer system has a user interface allowing a user to selectively view information regarding one or more projects. The relational database also provides interfaces and methods for accessing and manipulating and analyzing project-based information.

Project-based full-length biomolecular sequence database with expression categories

The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.

Database for storage and analysis of full-length sequences

Project-based full length biomolecular sequence database

Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. The hierarchies allow searches for sequences based upon a protein's biological function or molecular function. Also disclosed is a mechanism for automatically grouping new sequences into protein function hierarchies. This mechanism uses descriptive information obtained from 'external hits' which are matches of stored sequences against gene sequences stored in an external database such as GenBank. The descriptive information provided with the external database is evaluated according to a specific algorithm and used to automatically group the external hits (or the sequences associated with the hits) in the categories. Ultimately, the biomolecular sequences stored in databases of this invention are provided with both descriptive information from the external hit and category information from a relevant hierarchy or hierarchies.

Database system employing protein function hierarchies for viewing

The present invention provides polynucleotides and related reagents which are associated with pancreatic and other cancers. These polynucleotides are designated PANC1A.

Polynucleotides encoding a protein associated with pancreatic cancer

Growing community of inventors

Newbury Park, CA, United States of America

Ingrid E Akerblom