Heumann Pharma Gmbh & Co.

Ludwig Heumann & Co. Gmbh

Ingomar Grafe

Kurt H Ahrens

Helmut Schickaneder

Walter Otto Liebenow

Lothar Kisielowski

Peter W Jungblut

Kurt Henning Ahrens

A new process for the preparation of 2,6-dichlorodiphenylamine derivatives is described, which process provides the desired active compound in a high yield and with a very high degree of purity by a technically simple and realizable procedure.

Process for the preparation of 2,6-dichlorodiphenylaminoacetic acid

This invention relates to new stereochemically pure and stable adducts of Z-1-(p-.beta.-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but- 1-ene and certain solvents which by virtue of their marked antioestrogenic activities may be used for the therapeutic treatment of benign breast diseases and hormone-dependent mammary tumors, in particularly by percutaneous application.

Stable solvent adducts of

A new anhydrous crystalline form of prazosine hydrochloride characterized by the following bands in the infra-red spectrum in potassium bromide is described:

Crystalline, anhydrous sigma-form of

A simplified process for the preparation of basically substituted phenylacetonitriles, in particular of verapamil, is described. This process is carried out with fewer stages and higher yields than the known processes according to the state of the art.

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Nuremberg, Germany

Ingomar Grafe