Merck Patent Gmbh

Ingo Kober

Kai Schiemann

Melanie Schultz

Andree Blaukat

Wolfgang Staehle

Ramesh Kumar Sistla

Didier Roche

Francis Contard

Gérard Botton

Saumitra Sengupta

Dirk Wienke

Mireille Krier

Serge Christmann-Franck

Gisèle Mautino

Gummadi Venkateshwar Rao

Compounds of the formula (I), in which R, R, R, D, G, Q and W have the meanings indicated in Claim (), can and be employed for the treatment of tumors.

Piperidine and piperazine derivatives

Compounds of the formula (I), in which R, R, R, D, G, Q and W have the meanings indicated in claim (), can and be employed for the treatment of tumors.

The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms of disease or disorders related to the activity of FXR. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I). 

Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators

Compounds of the formula (I), in which R, R, R, R, K, G, E and W 

Thiazole derivatives

The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer

Growing community of inventors

Gross-Gerau, Germany

Ingo Kober