Bayer Aktiengesellschaft

Ingo Haller

Karl G Metzger

Hans-Joachim Zeiler

Rainer Endermann

Klaus Grohe

Uwe Petersen

Michael Schriewer

Thomas Schenke

Manfred Plempel

Karl H Buchel

Andreas Krebs

Erik Regel

Wolfgang Kramer

Wilfried Draber

Klaus-Dieter Bremm

Graham Holmwood

Gunter Schmidt

Klaus Sasse

Horst Boshagen

Franz Kunisch

Wilfried Schrock

Wolfgang Hartwig

Thomas Philipps

Hanno Wild

Karl-Georg Metzger

Hans-Rudolf Pfaendler

Wolfgang Hartiwg

Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##

Preparation of 7-(3-amino- and

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen, X.sup.2 is hydrogen, halogen, amino or other radical, R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical, R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.

7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic acid

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partly hydrogenated isoindolinyl ring, processes for their preparation and antibacterial agents and feed additives containing these compounds.

7-isoindolinyl-quinolone-carboxylic acid derivatives

An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,

Quinolone- and naphthyridone carboxylic acid derivatives, process for

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,

7-(1-pyrrolidinyl)-3-quinolone carboxylic acid derivatives as

The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and anti-bacterial agents and feed additives containing them.

7-(2,7-diazabicyclo[3.3.0]octyl)-3-quinolone-and-naphthyridonecarboxylic

Quinolone- and naphthridone carboxylic acid derivatives, process for

Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 - alkyl,

Antibacterial 5-alkylquinolonecarboxylic acids

The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and antibacterial agents and feed additives containing them.

7-(2,7-diazabicyclo[3.3.0]octyl)-3-quinoline- and

Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxlyic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,

Antibacterial

.beta.-Lactam compounds of the formula ##STR1## wherein R.sup.5 represent cyclopropyl or methyl, useful as antibiotics.

Substituted vinylcephalosporins

Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 -alkyl,

A pharmaceutical preparation comprising an antibiotic, a pharmaceutical excipient therefor, and in addition an oxapenem-3-carboxylic acid of the formula ##STR1## or a pharmaceutically acceptable salt, ester or amide in which R.sup.1 and R.sup.2 each independently is hydrogen or a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds, and in which

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Wuppertal, Germany

Ingo Haller