Pls-design Gmbh

Ingke Braren

Thomas Grunwald

Reinhard Bredehorst

Henning Seismann

Henning Selsmann

The invention relates to nucleic acids encoding a novelvenom protease or fragments thereof, in particular the protease Ves v 4, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to the expression of such nucleic acids to produce a recombinantvenom protease, or recombinant fragments thereof, or synthetic peptides thereof. Such a protease or fragments thereof or synthetic peptides thereof are useful for diagnosis of insect venom allergy and for therapeutic treatment of insect venom allergy.

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The instant application inter alia relates to chimeric fusion constructs comprising the extracellular portion of human Fc&#x3b5;RI&#x3b1; and at least one avian constant immunoglobulin domain and the use thereof for in vitro diagnostic purposes.

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Hamburg, Germany

Ingke Braren