Ge Healthcare Bio-sciences Ab

Amersham Biosciences Ab

Magle Holding Ab

Ge Healthcare Bioprocess R&d Ab

Nicachet Ab

Ingemar Jonsson

Ralf Goran Andersson

Anders Larsson

Hans Berg

Hans Henrik Lidgard

Gustaf Plym Forshell

Ralf Göran Andersson

Hans c/o Amersham Biosciences Ab Berg

Anders c/o Amersham Biosciences Ab Larsson

The invention refers to a composition material that is intended for rapid transmucosal delivery in the mouth of a biologically active substance when in contact with saliva. The composition material comprises at least one ionic carbohydrate, having at least one biologically active substance ionically bound thereto, and at least one wetable non-soluble polymeric carbohydrate. The invention also refers to a method of preparing the composition material, which comprises the steps of: (a) providing a mixture of the at least one biologically active substance and at least one ionic carbohydrate in a solvent having a permissive pH for ionic bonding of the at least one biologically active substance to the at least one ionic carbohydrate; (b) mixing the mixture in the solvent for a period that is sufficient for allowing the ionic bonding to take place; and (c) recovering the mixture from the solvent.

Composition material for transmucosal delivery

The present invention is a process of manufacture of one or more polysaccharide beads, comprising generating an aerosol of an aqueous polysaccharide solution, cooling the droplets of said aerosol in air to initiate gelling thereof and collecting droplets as gelled beads in a liquid or on a surface, characterised by adding a hydrophilic vapour pressure-lowering agent to said polysaccharide solution.

Manufacture of polysaccharide beads

Method and device for continuously producing a coherent layer of a liquid/melt of even thickness by means of centrifugal action along the entire periphery of a rotating disk (), liquid/melt being supplied to the disk around its entire axis of rotation from means () and leaving the disk as individual droplets. The means () distributing the liquid/melt onto the disk () has according to the invention essentially the same speed and direction of rotation as the disk, and the liquid/melt undergoes under the influence of centrifugal action circumferentially a spreading and change in velocity across the disk () in contact with the same.

Method and device for producing a coherent layer of even thickness of liquid or melt on a rotating disk

The invention refers to a method of controlling the porosity of porous spherical particles produced from a polysaccharide dissolved in a solvent, in which it can be gelled. The polysaccharide solution is finely divided by mechanical means into spherical droplets which are allowed to pass through a humid atmosphere and transferred to a capturing medium while controlling the temperature and humidity of humid atmosphere.

Method of producing porous spherical particles

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Helsingborg, Sweden

Ingemar Jonsson