A. Carlsson Research Ab

Nsab, Filial Af Neurosearch Sweden Ab

Ingela Marianne Svan

Clas Sonesson

Joakim Tedroff

Nicholas Ross Waters

Susanna Waters

Anders Kristoffer Lilja

Liselott Lilja Rönnqvist

Jenny Maria Carlberg

Nicholas Waters

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bind at the dotted line; Ris CF, OSOCF, OSOCH, SOR, SOR, COR, CN, OR, NO, CONHR, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; Ris F, Cl, Br, I, CN, CF, CH, OCH, OH, and NH; Rand Rare independently H or a C-Calkyl; Ris a C-Calkyl, an allyl, CHSCH, CHCHOCH, CHCHCHF, CHCF, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or &#x2014;(CH)R; Ris a C-Ccycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane; Ris a C-Calkyl, CF, or N(R), and pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.

Modulators of dopamine neurotransmission

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; Ris OSOCF, OSOCH, SOR, SOR, COR, NO, or CONHRand when X is CH or C Rmay also be CF, CN, F, Cl, Br, or I; Ris a C-Calkyl, an allyl, CHSCH, CHCHOCH, CHCHCHF, CHCF, 3,3,3-trifluoropropyl, 4,4,4,-trifluorobutyl, or &#x2014;(CH)&#x2014;R; Ris a C-Calkyl CF, or N(R); Ris a C-Ccycloalkyl, 2-tetrahydrofurane or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed

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Göteborg, Sweden

Ingela Marianne Svan