Merck Patent Gesellschaft MIT Beschrankter Haftung

Inge Stein

Michael Schwarz

Ulrich Heywang

Michael Kompter

Eike Poetsch

Volker Meyer

Steffen Neuenfeld

Andrew Barber

Klaus Beschmann

Holger Beeres

The invention relates to a novel heat-stable form of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diph enylacetamide and to a process for the preparation and isolation of this compound in this novel form and to use for the production of medicaments which contain this compound and/or one of its physiologically acceptable salts.

N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2

The use of a benzylidenenorcamphor compound of the formula I ##STR1## wherein Phe is a phenyl group which is unsubstituted or substituted by 1 to 5 hydroxyl, alkyl or alkoxy groups having 1 to 10 C atoms, and n is 1 or 2. as sunscreen filters, and also novel compounds of the formula I, their preparation and use as UV filters, in particular in cosmetic or pharmaceutical preparations.

Benzylidenenorcamphor derivatives

The invention relates to ketotricyclo�5.2.1.0!decane derivatives of the formula I ##STR1## wherein Phe is a phenylene group which is unsubstituted or substituted by 1 to 4 hydroxyl, alkyl or alkoxy groups having 1 to 10 C atoms, and their preparation and use as UV filters, in particular in cosmetic or pharmaceutical preparations.

Ketotricyclo �.5.2.1.0! decane derivatives

The invention relates to bis(methylidene)phenylene derivatives of the formula

Bis(methylidene)phenylene derivatives

A process for preparing substituted 4-methylidenecinnamic acid derivatives of Formula (I). ##STR1## The variables are defined herein. The compounds of Formula (I) can be used, for example, as UV absorbers.

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Rodgau, Germany

Inge Stein