Orion-yhtyma Oy

Inge-Birtt Linden

Erkki J Honkanen

Reijo J Backstrom

Atso Raasmaja

##STR1## Substituted cyclic hydroxamic acids of general formula (I) in which R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, halogen, lower alkyl, lower alkoxy, cycloalkoxy, aryloxy which is optionally substituted by 1 to 3 halogen, or aralkyloxy, which is optionally substituted by 1 to 3 halogen, or R.sub.1 and R.sub.2 together form a --O--CH.sub.2 --O-- group; with the proviso that R.sub.3 is not hydrogen when R.sub.1 and R.sub.2 are both hydrogen; R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl, R.sub.6 is hydrogen or lower alkyl and physiologically acceptable salts and esters thereof are selective inhibitors of phosphodiesterase IV activity and leukotriene B.sub.4 and C.sub.4 synthesis without showing any significant effect on phosphodiesterase III activity, and are therefore useful in the treatment of hypersensitivity and inflammatory diseases.

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Helsinki, Finland

Inge-Birtt Linden