Academia Sinica

Academic Sinica

Ing-Chien Chen

An-Suei Yang

Chung-Ming Yu

Chao-Ping Tung

Hong-Sen Chen

Yi-Kai Chiu

Yi-Jen Huang

Yu-Ching Lee

Keng-Chang Tsai

Hung-Ju Hsu

Hung-Pin Peng

Shin-Chen Hou

Hung-Ju Chang

Chi-Kai Yang

Cheng-Chung Lee

Hwei-Jiung Wang

Yueh-Liang Tsou

Chia-Lung Lin

Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.

Method for high-throughput screening of neutralizing antibodies, neutralizing antibodies produced therefrom, and uses thereof

Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Recombinant antibody and uses thereof

Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Phage-displayed antibody libraries and uses thereof

Phage-displayed single-chain variable fragment library

Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.

Phage displaying system expressing single chain antibody

Growing community of inventors

Taipei, Taiwan

Ing-Chien Chen