Biomay Ag

Mead Johnson Nutrition Company

Biomay Produktions- Und Handelsaktiengesellschaft

The University of Melbourne

Ines Swoboda

Rudolf Valenta

Peter Valent

Susanne Spitzauer

Susanne Vrtala

Margarete Focke-Tejkl

Birgit Linhart

Dietrich Kraft

Mohan Bir Singh

Hans Grönlund

Udo Herz

Kerstin Westritschnig

Katharina Blatt

Theresia Popow-Kraupp

Marianne Van Hage

Ric Van Tol

Nicole Deweerd

Prem L Bhalla

Anna Gieras

Raffaela Campana

Ulrike Schulmeister

Margarte Focke-Tejkl

Heidrun Hochwallner

Rudolph Valenta

Johanna Tinhofer

Renate Reininger

Eric AF Van Tol

The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.

Vaccine carrier

A method for identifying allergenic proteins and peptides. More specifically, a method for identifying allergenic milk proteins and/or peptides including the steps of: providing at least one expression library comprising DNA or cDNA derived from the mammary gland tissue of a lactating cow, expressing at least one protein or peptide encoded by said expression library, determining the binding capacity of said at least one protein or peptide to IgE of at least one serum of an individual who is sensitive to cow's milk, contacting the at least one protein or peptide exhibiting an IgE binding capacity as determined in step c) with basophil cells, eosinophil cells or mast cells and identifying the at least one protein or peptide as being allergenic when said basophil cells, eosinophil cells or mast cells release upon contact with at least one protein or peptide of step d) at least one mediator.

Method for identifying allergenic proteins and peptides

Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.

Hypallergenic mosaic antigens and methods of making same

The present invention relates to non-naturally occurring polypeptides derived from fish allergens such as parvalbumin Cyp c 1.01 from carp. The polypeptides display reduced allergenic activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.

Hypoallergenic mutant polypeptides based on fish parvalbumin

Growing community of inventors

Vienna, Austria

Ines Swoboda