Massachusetts Eye and Ear Infirmary

Ines Maria De Carvalho Lains

Deeba Husain

Joan W Miller

Edem Tsikata

John Miller

Teresa C Chen

This disclosure relates to biomarkers for Age-Related Macular Degeneration (AMD) and methods of use thereof, e.g., methods of the use of biomarkers for determining that a subject has Age-related Macular Degeneration (AMD) or determining the stage of AMD in a subject.

Biomarkers for age-related macular degeneration

The disclosure features methods and systems that include: obtaining an input image of an imaging subject, where the input image is a color image featuring, in each of multiple color channels, a first set of pixel intensity values; for each one of the multiple color channels, determining a measured contrast value and a measured brightness value from the first set of pixel intensity values for the color channel, determining a contrast ratio for the color channel based on a target contrast value for the color channel and the measured contrast value for the color channel, and generating a second set of pixel intensity values for the color channel; and generating an output image of the imaging subject based on the second sets of pixel intensity values for each of the multiple color channels.

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Cambridge, MA, United States of America

Ines Maria De Carvalho Lains