Pliva Hrvatska D.o.o.

Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo

Ines Fistri&cacute;

Aleksandar Danilovski

Bozena Klepi&cacute;

Miljenko Dumi&cacute;

Darko Fili&cacute;

Jasna Horvat Mikul{haeck Over (c)}i&cacute;

Jasna Horvat Mikulci&cacute;

Marina Oresi&cacute;

Marina Ore{haeck Over (s)}i&cacute;

The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.

Crystal modification of torasemide

The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.

Growing community of inventors

Zagreb, Croatia

Ines Fistri&cacute;