Cytos Biotechnology Ag

Kuros Biosciences Ag

Indulis Cielens

Martin F Bachmann

Alain Tissot

Paul Pumpens

Regina Renhofa

Patrik Maurer

Edwin Meijerink

Katrin Schwarz

Gerd Lipowsky

Tazio Storni

Wolfgang Andreas Renner

Vania Manolova

Sebastian Fuchs

Conrad Coester

Klaus Dietmeier

Yu Zou

The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.

Packaging of immunostimulatory substances into virus-like particles: method of preparation and use

The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.

Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.

Molecular antigen arrays

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Riga, Latvia

Indulis Cielens