Virginia Commonwealth University

Sanofi Pasteur Vaxdesign Corporation

Vaxdesign Corporation

Inderpal Singh

William L Warren

Eric Mishkin

Donald Drake

Haifeng Song

Janice Moser

John G Tew

Mohey Eldin M El Shikh

Donald Drake Iii

Donald Iii Drake

Eric Mihkin

Mohey Edin M El Shikh

The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

Methods for testing an immune response using cultures of T cells, B cells, dendritic cells and follicular dendritic cells

Methods for testing an immune response using cultures of T cells, B cells and dendritic cells

Method for determining the immunogenicity of an antigen

Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)

The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies.

Models for vaccine assessment

Growing community of inventors

Orlando, FL, United States of America

Inderpal Singh