Synphar Laboratories, Inc.

Taiho Pharmaceutical Company Limited

Inderjit Sidhu

Ronald G Micetich

Dai Q Nguyen

Mohsen Daneshtalab

Norio Unemi

Inder Pal Singh

Jehangir Khan

Ronald J Micetich

Chan M Ha

Bhupinder Palak

Sameeh Salama

Mark Abel

Yadagiri Bathini

Tetsuo Furukawa

A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.

Triazoles as therapeutic agents for fungal infections

The asymmetric production of pure diastereomeric (2R,3R), (2R,3S), (2S,3R) and (2S,3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.

Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl

A process for the synthesis of compounds of the formulas Ia and Ib below, wherein R.sub.1, R.sub.2, and R.sub.3, which are the same or different, are each selected from hydrogen and C.sub.1 -C.sub.4 alkyl, including the compound Anabaseine (Ia, wherein R.sub.1 =R.sub.2 R.sub.3 =H) (3,4,5,6-tetrahydro-2', 3'-bipyridine), the process comprising reacting sodium salt of .delta.-valerolactone with substituted ethyl nicotinate derivative to produce the Claisen product sodium 3-nicotinoyl-2-tetrahydropyranone enolate derivative, heating the sodium 3-nicotinoyl-2-tetrahydropyranone enolate derivative with concentrated HCl to produce 3-(5-chloro-1-pentanone-1-yl) pyridine derivative, dissolving the 3-(5-chloro-1-pentanone-1-yl) pyridine derivative in ethanol and then heating the 3-(5-chloro-1-pentanone-1-yl) pyridine derivative in ethanol with ethanolic ammonia solution in a sealed container to produce the compound Ia. Also, the process steps in the above process, and the products and intermediate products produced thereby. ##STR1##

Synthesis of anabaseine, salts and derivatives thereof

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Edmonton, Canada

Inderjit Sidhu