Bristol-Myers Squibb Compnay

Indawati DeLucca

Wu Yang

Peter W Glunz

Andrew K Dilger

Donald J P Pinto

Michael J Orwat

Jennifer X Qiao

Leon M Smith, Ii

Yufeng Wang

Tammy C Wang

Yoon T Jeon

Charles G Clark

Patrick Y S Lam

Manoranjan Panda

Carol Hui Hu

Carl Thibeault

Kumar Balashanmuga Pabbisetty

Vladimir Ladziata

Scott A Shaw

Leon M Smith Ii

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Spiroheptane salicylamides and related compounds as inhibitors of ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same. 

Spirolactams as inhibitors of ROCK

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Yreceptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders. 

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Indawati DeLucca