Daewoong Pharmaceutical Co., Ltd.

Volvo Construction Equipment Ab

Daewoong Co., Ltd.

In Woo Kim

Ji Duck Kim

Jun Hee Lee

Chang Soo Lee

Jin Seop Kim

Sun Ah Jun

Nam Youn Kim

Hyae Jung Hyun

Hong-Chul Yoon

Hong Chul Yoon

Young Ok Park

Seung Hwarn Jeong

Min Hee Cho

Sang Ho Lee

Joon Seok Park

In Young Lee

Ha Young Kim

Soo Jin Choi

Mi Ryeong Han

Joon Hwan Lee

Ja Kyung Yoo

Yun Soo Yoon

Hyo Shin Kim

Byung Goo Lee

Hee Kyoon Yoon

Sang Hyun Nam

Hyung Geun Lee

Min Jae Cho

Yun Soo Na

Jakyung Yoo

Kwon Jo Lim

Young Mook Lim

Eun Kyung Park

Kyung Ha Chung

Yun Ju Oh

Bo-Kyoung Kim

Ji Duck 401-1701 Seohong Maeul Hyosung Apt Kim

Chang Soo 101-401 Woosung Apt 17-1 Lee

The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions: 

Substituted piperidines as kinase inhibitors

The present invention relates to a compound represented by the Chemical Formula 1 defined in the present specification, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions. 

Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors

The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions.

Amino-fluoropiperidine derivatives as kinase inhibitor

The present invention relates to a pyrazolopyrimidine derivative, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions.

Pyrazolopyrimidine derivatives as kinase inhibitor

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers, preparation method thereof and use thereof

Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Benzoimidazole derivatives and pharmaceutical composition comprising the same

This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

Method of preparing benzoimidazole derivatives

Disclosed are biaryl benzoimidazole derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same

A step apparatus for heavy construction equipment and tree harvester having a leveling system for controlling a horizontal level of a cab and an upper frame is provided, which includes a step protector including a main body fixedly installed on one side of an upper frame, a step guide hole opened from an inside of the main body to an outside, a guide rail formed along a length direction of an inner side wall of the main body, and an insert hole formed on one side of the guide rail and open toward a vertically upward direction of the guide rail; a side step including a plurality of foot steps arranged at specified intervals on a step frame to form stairs, a step drawer formed on an upper part of the step frame and seated in the step guide hole, and a guide pin positioned adjacent to the step drawer and projected toward the side wall of the main body, wherein when the guide pin is slid along the guide rail, the step frame is seated in the main body or is drawn out from the inside of the main body; and a folding actuator including a cylinder rod coupled to the step drawer to be extended and contracted, the folding actuator drawing the step drawer to the inside of the main body of the step protector.

Step apparatus for heavy construction equipment and tree harvester having leveling system

Disclosed are biaryl benzoimidazo derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same

A leveling control system and method for heavy equipment, in which a lower frame having a traveling unit and an upper frame are combined together by a tilting unit, includes a sensor unit, provided in the equipment, for measuring twist angles of the lower frame and the upper frame against a reference horizontal surface and a traveling speed of the equipment, and detecting working state information of working devices; a control unit for receiving the twist angles, the traveling speed, and the working state information, calculating a correction angle for the leveling control of the upper frame, and generating a control signal for instructing an operation of an actuator in accordance with the correction angle; and a driving unit for performing the leveling through the actuator in accordance with the control signal received therein.

Leveling control system and method for heavy equipment

An image display system for controlling automatic leveling of heavy equipment is provided. The image display system includes the leveling means for adjusting horizontal levels of a lower frame provided with a traveling means and an upper frame having a cab and installed on an upper part of the lower frame, a sensor unit for sensing posture information of the heavy equipment, a leveler electronic control unit for generating an image signal from the posture information, and an image display unit for displaying the image signal on a display screen. The posture information includes inclination angles of the upper frame and the lower frame sensed on the basis of a horizontal surface against a direction of gravity, an azimuth angle of the heavy equipment sensed against a forward direction of the upper frame, and a swing angle of the upper frame sensed on the basis of a front direction of the lower frame. According to the image display system, the leveling state of the heavy equipment is easily recognized, and the control performance of the heavy equipment is improved.

Image display system for controlling automatic leveling of heavy equipment

A leveling control system and method for heavy equipment, in which a lower frame having a traveling unit and an upper frame are combined together by a tilting unit. The system includes a sensor unit, provided in the equipment, for measuring twist angles of the lower frame and the upper frame against a reference horizontal surface and a traveling speed of the equipment, and detecting working state information of working devices; a control unit for receiving the twist angles, the traveling speed, and the working state information, calculating a correction angle for the leveling control of the upper frame, and generating a control signal for instructing an operation of an actuator in accordance with the correction angle; and a driving unit for performing the leveling through the actuator in accordance with the control signal received therein. The control unit is provided with an auto leveling mode module for performing the leveling against a reference horizontal surface, a re-leveling mode module for performing the leveling against the reference horizontal surface in a standstill state of the equipment for a limited time, and a track leveling mode module for performing the leveling against the lower frame.

A system and method for controlling automatic leveling heavy construction equipment. The system has a lower frame and an upper frame, the lower frame having a traveling unit, and the upper frame being tiltably and swingably connected to the lower frame. The system comprises a sensor unit, provided in the equipment, including an inclination detecting sensor for measuring twist angles of the lower frame and the upper frame against a reference horizontal surface, a traveling detection sensor for measuring a traveling speed of the equipment, and a working device sensor for detecting working state information of a working device. A control unit receives the twist angles, the traveling speed, and the working state information, calculates a corrected angle at which the upper frame is to be tilted against the lower frame, and generates a control signal for instructing an operation of an actuator. A driving unit performs a leveling control through the actuator in accordance with the received control signal.

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Seoul, South Korea

In Woo Kim