Kyungpook National University Industry-academic Cooperation Foundation

The Asan Foundation

In Kyu Lee

Chang Joo Oh

Dong Ho Park

Jae Han Jeon

Eun Jung Choi

Keun Gyu Park

Chang Hyun Jeon

Tae-Hwan Kwon

Han Jong Kim

Hyeon-Ji Kang

Joon-Young Kim

Ji Min Lee

Eun Hee Koh

Jung Eun Jang

Ki Up Lee

Joong Yeol Park

The present invention relates to a composition for prevention or treatment of hypercortisolemia, the composition comprising allithiamine, fursultiamine, and benfotiamine, which are all derivatives of thiamine, or a mixed composition thereof. The composition for prevention or treatment of hypercortisolemia of the present invention can effectively treat or alleviate symptoms or disorders resulting from excessive secretion of cortisol, without surgical operations, and does not exhibit side effects caused by conventional medications.

Composition, comprising thiamine derivative, for prevention or treatment of hypercortisolemia

The present disclosure pertains to a pharmaceutical composition comprising fursultiamine or a salt thereof for prevention or treatment of macular degeneration. Fursultiamine decreases the upregulated expression of HIF-1α in retinal pigment epithelial cells and suppresses the growth of choroidal vascular endothelial cells. The pharmaceutical composition comprising fursultiamine or salts thereof according to the present disclosure can be used as a therapeutic agent for various neovascular ocular diseases.

Composition for prevention or treatment of macular degeneration

The present disclosure is a pharmaceutical composition for the prevention or treatment of sepsis containing a thiamine derivative or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition of the present disclosure can be used for the prevention, alleviation, or treatment of sepsis by containing fursultiamine or allithiamine to inhibit the expressions of CD40, CD86, and TNFα.

Pharmaceutical composition containing thiamine derivative for prevention or treatment of sepsis

The present invention relates to: a pharmaceutical composition for preventing or treating vascular or cardiac valvular calcification, containing a thiamine derivative or a pharmaceutically acceptable salt thereof; and a food composition for alleviating vascular or cardiac valvular calcification, containing a thiamine derivative or a salt thereof, and the compositions of the present invention can be effectively used for a use of preventing, treating or alleviating vascular or cardiac valvular calcification.

Composition for treating vascular or cardiac valvular calcification, containing thiamine derivative

The present invention relates to a composition for preventing or treating renal fibrosis comprising dimethylfumarate (DMF) as an active ingredient. The DMF according to the present invention has an excellent effect of reducing renal fibrosis by activating Nrf2 to inhibit TGF-&#x3b2;/Smad signaling, and thus is useful for preventing or treating renal fibrosis.

Composition for preventing or treating renal fibrosis comprising dimethylfumarate as active ingredient

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Daegu, South Korea

In Kyu Lee