Yuhan Corporation

Samsung Electronics Co., Ltd.

Yonsei University

In Hwan Lim

Moo Young Song

Byung Hyun Choi

Sung Ho Kim

Dong Uk Kim

Ki Hong Kim

Jun Young Park

Jong Gyun Kim

Jin Hyoung Lee

Geun Tak Kim

Yun Ju Jeong

Jin-Hyoung Lee

Hee Kyung Sung

Jun Hwan Kim

Jung-Sun Lee

Hyoung Sig Seo

Jin Sook Yoon

Hae Yong Jo

Cheol Ryong Ku

Taejin Yoon

Man Sil Park

Hyeon Woo Kang

Eun Jig Lee

A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.

Method for producing dual function proteins and its derivatives

Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.

Fusion protein comprising thyrotropin receptor variants and use thereof

Disclosed is a method of preparing a stabilized liquid formulation of a protein drug, comprising admixing a protein drug with a composition for stabilization, wherein the composition for stabilization comprises a surfactant, a buffer, and a liquid medium, and has a pH from about 5 to about 8.

Liquid formulation containing a protein drug

Growing community of inventors

Suwon-si, South Korea

In Hwan Lim