Gyogyszerkutato Intezet Kft.

Egis Gyogyszergyar

Richter Gedeon Vegyeszeti Gyar Rt

Egis Gyogyszergyar Rt.

Other

Biogal Gyogyszergyar Rt.

Biogal Gyogyszergyar

Egyt Gyogyszervegyeszeti Gyar

Patentbureau Danubia

Gyogyszerkutato Intezet

Ivax Drug Research Institute

Richter Cedeon Vegveszeti

Richer Gedeon Vegyeszet

Cyogyszerkutato Intezet Kft

Gis Gyogyszergyar Rt.

Imre Moravcsik

Tamas Hamori

Ferenc Andrasi

Jeno Korosi

Pal Berzsenyi

Peter Botka

Gabor Ambrus

Katalin Goldschmidt

Istvan Tarnawa

Antal Simay

Gyula Horvath

Sandor Farkas

Tibor Lang

Gabor Zolyomi

Eva Ilkoy

Sandor Bajusz

Istvan Elekes

Tibor Balogh

Istvan M Szabo

Attila Andor

Eva Barabas

Antonia Jekkel

Attila Juhasz

Ferenc Szederkenyi

Kalman Konczol

Katalin Horvath

Gabor Kovacs

Istvan Gyertyan

Kalman Nagy

Jozsef Reiter

Sandor Elek

Zoltan Zubovics

Janos Borvendeg

Janos Erdei

Gyorgy Rabloczky

Karoly Albrecht

Pal Vago

Istvan Ling

Gyorgy Krasznai

Gyorgy Somogyi

Istvan Pallagi

Gyorgy Santha

Erno Orban

Maria Kuhar Nee Kurthy

Eszter Szentkuti

Gabor Toth

Antonia Jekkel Nee Bokany

P&aacute;l Berzsenyi

Eva Toth-Sarudy

Kalman Polya

Jozsef Lango

Lajos Ila

Emese Csuzdi

Anna Bakonyi

Zsuzsanna Lang Nee Rihmer

Lajos Toldi

Laszlo Szporny

Gyula Simig

Gyorgy Hajos

Gabor Gigler

Istvan Gacsalyi

Gabor Blasko

Gyorgy Cseh

Gyula Papp

Istvan Polgari

Andras Egyed

Peter Matyus

Sandor Solyom

Inge Schafer

Giorgio Cignarella

Valeria Szell

Andrea Maderspach

Andras Varro

Daniel Bagdy

Ilona Hermann Nee Szente

Laszlo Cseke

Katalin Horv&aacute;th

Erzsebet Szell Nee Hasenohrl

Melinda Gal

Karoly Tihanyi

Marta Szollosy

Andras Bilkei-Gorzo

Jozsef Szekely

Sandor Boros

Katalin Eszter Horvath

Andras Javor

Emilia Simonovits

Gyorgy Botond Kiss

Gizella &Aacute;brah&aacute;m

Bela Makadi

Istvan Ott

Istv&aacute;n Tarnawa

Istv&aacute;n Ling

Ferenc Andr&aacute;si

Alice Druga

Tivadar Rettegi

Ildik&oacute; Varga

P&eacute;ter M&aacute;tyus

Pal Bite

Judit Bajnogel

In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.

Process for the isolation and purification of mevinolin

Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds

(3R)-3-amino-4-carboxybutyraldehyde derivatives inhibiting the release of interleukin-1/beta

2,3-benzodiazepine derivatives

The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1)

Antiarrhythmic compounds

Anticoagulant peptidyl-arginine aldehyde derivatives

Anticoagulant peptide aldehyde derivatives

The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.

1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine

This invention relates to new 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.

1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives

Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions. A process to make the 2,3-benzodiazepine derivatives includes converting starting compounds which are substituted by one or two halogen groups and have the general formula ##STR2##

2,3-Benzodiazepine Derivatives as non-competitive AMPA

Anticoagulant peptide derivatives and pharmaceutical compositions

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)

N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic

The invention relates to novel N-acyl-2,3-benzodiazepine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I), defined in this specification, a more complete description of the compounds may be found. The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.

N acyl 2 3 benzodiazepine derivatives pharmaceutical compositions

The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms. Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with isolated promoters and signal sequences, subsequently the expression/secretion cassettes comprising the foregoing elements were inserted into plasmid DNAs allowing the cultivation of cells under selective culture conditions. E. coli, Saccharomyces and Streptomyces species were transformed with the said recombinant plasmids to biosynthesize the thrombin inhibitor desulphatohirudin HV-1 which was then isolated and identified. The thus-produced desulphatohirudin can be used to inhibit blood coagulation.

Plasmids and process for producing recombinant desulphatohirudin HV-1

N-acyl-2,3-benzodiazepine derivatives pharmaceutical compositions

Growing community of inventors

Budapest, Hungary

Imre Moravcsik