Creighton University

Reanal Finomvegyszergyar

Solvo Biotechnology

Mta Kutatas-es Szervezetelemzo Intezete

Biosignal Kutato-fejlesztokft

Richter Gedeon Veyteszeti Gyar R.t.

Imre Mezo

Istvan Teplan

Janos Seprodi

Zsolt Vadasz

Aniko Horvath

Balazs Szoke

Istvan Palyi

Borbala Vincze

Judit Horvath

Orsolya Csuka

Magdolna Kovacs

Sandor Lovas

Gyorgi Keri

Geza Toth

Karoly Nikolics

Gabor Makara

Judit Erchegyi

Ferenc Antoni

Adrienn Kalnay

J Michael Conlon

Sandor Vigh

Gyorgy Rappay

Edit Hegedus

Agnes Balogh

Balas Szoke

Miklos Idei

Gyongyi Bokonyi

Dezso Gaal

Maria Magocsi

Andras Szell

Judit Rchegyi

The invention features novel peptide derivatives called Reversins, and provides for their use in a method of reducing the activity of the multi-drug transporter protein MDR1 in order to overcome multidrug resistance in a mammal. The peptide derivatives are of the formula (I) X,-X,-X,(X,),-X,, wherein n is 0 or 1, and each n is the same or different; X,is BOC, BOC-Asu, Z-Asu, benzyloxycarbonyl, Glu(OBzl)-OBzl, Trp-OMe, Trp-Phe-OMe, Phe-Trp-OMe, Phe-Phe-OtBu, Trp-Trp-OtBu, indoloacetyl, benzoyl, an alkylanine of 1-4 carbons, dibenzylamide, tryptamide, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylamide or dicyclohexylamide; X,is Glu(OBzl), Asp(OBzl), succinyl, O,O-dibenzoyltartaroyl, diphenoyl, muconyl, Thx, Cpa, Asu, Nal, Pen, Phg, Dbt, Lys(BOC), Lys(Z), Cys(Bzl), Thr(Bzl), Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Phe, Tyr(Bzl), or Ser(Bal); X,is Asp, Asu, Lys, Glu, Trp, Thx, Cpa, Nal, Pen, Phg, Dbt, Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Tyr, Phe, or Tyr(Bzl); X,is BOC-Glu(OBzl), Glu(OBzl), Asu, OBzl, Bzl, BOC, BOC-Lys(BOC), Z-Glu(OtBu), Asp(OBzl), Asp(OBz)-OBzl, benzyloxycarbonyl, O-(cyclo-hexyl), fluorenylmethyl ester, Glu(OtBu), Glu(OtBu)-OBzl, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylarnide, or dicyclohexylamide; and X,is OMe, OBzl, OtBu, Phe-OMe, -O-(cyclohexyl), Trp-OMe, (chlorophenyl)-isobutylamide, fluorenylmethyl ester, ONp, 1-aminoadamantane, aminomethylcyclohexane, indoline, phenylethylamide, or dicyclohexylamide.

Compounds for reversing drug resistance

The present invention provides a novel pharmaceutical composition for the treatment of breast cancer. Also provided are various methods of treating breast cancer.

Anti-tumor effects of GnRH-III

The invention relates to tumor-inhibiting heptapeptide and octapeptide amide derivatives and to a method of treating mammals, including men, suffering from tumors or from the excessive secretion of insulin, glucagon or growth hormone using these compounds.

Tumor growth-inhibiting somatostatin analogues, pharmaceutical

The invention relates to new peptides of the formula ##STR1## wherein R.sup.2 represents Ala or D-Ala,

Analogs of growth hormone releasing factor (GRF) and a method for the

The invention relates to novel gonadoliberine derivatives of the general formula (I) ##STR1## wherein X represents an --O--R group wherein R is a benzyl group or a C.sub.1-4 alkyl group, an ##STR2## group wherein R1 and R2 independently stand for hydrogen, a C.sub.1-5 alkyl, aryl, aryl-C.sub.1-2 -alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group,

Gonadoliberin derivatives containing a .beta.-aspartyl group, a process

Gonadoliberin derivatives process for the preparation and pharmaceutical

Growing community of inventors

Budapest, Hungary

Imre Mezo