Aktiebolaget Leo

Imre Konyves

Hans Jacob Fex

Krister A Holmberg

Bertil Hogberg

Bertil Hansen

Knut Bertil Hogberg

Anders Robert Stamvik

This invention relates to novel 17.alpha.-esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and method of treatment therewith.

Novel 17-esters of 17.alpha.-hydroxy gestogens, compositions containing

This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds and methods of treatment therewith.

Novel enol esters of steroids, compositions containing such compounds,

New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R.sup.1 can be hydrogen, lower alkyl, halogen, or lower alkoxy, X can be oxygen, sulphur, or a monovalent carbon-to-carbon bond, A can be alkylene, aminoalkylene, or lower-alkanoyl aminoalkylene, and A together with X also can be a monovalent carbon-to-carbon bond, with a corticoid steroid.

Cortical steroid nitrogen mustard compositions and treatment therewith

This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N.sup.4 halogenalkyl-N.sup.4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.

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Hittarp, Sweden

Imre Konyves