Richter Gedeon Vegyeszeti Gyar Rt

Egis Gyogyszergyar Rt.

Other

Richter Gedeon Nyrt.

Sudzucker Aktiengesellschaft Mannheim/ochsenfurt

Hajnal, Péter

Imre Klebovich

Edit Toth

Jozsef Torley

Laszlo Vereczkey

Laszlo Szporny

Eva Palosi

Sandor Gorog

Gyorgy Fekete

Istvan Hajdu

Pal Vittay

Attila Mandi

Zoltan Budai

Gabor Blasko

Pal Fekete

Sandor Drabant

Gyorgy Ujfalussy

Gyula Simig

Gyorgy Hajos

Tibor Mezei

Istvan Gyertyan

Istvan Gacsalyi

Kalman Nagy

Klara Reiter Nee Esses

Eva Schmidt

Andras Egyed

Gyula Lukacs

Ferenc Simon

Denes Bezzegh

Margit Csorgo

Eva Furdyga

Jörg Bernard

Peter Sarkozy

Erzsebet Barczay

Maria Kiraly Nee Ignacz

Ilona Sztruhar

Andras Selmeczi

Maria Krisztian

Marta Szanto

Biborka Maroshelyi, Nee Kovacs

Zsuzsa Szlavy, Nee Szell

Oliver Luhn

Andrea Sandorfalvy

PerjeIstvan

Magdolna Gora, Nee Hernyes

Erzsebet Fellner, Nee Kohalmi

Lao Szporny

Gabor Sipos

Zsuzsanna Jambor Nee Hoffmann

Attila Misley

Katalin Baloghne Nemes

Gizella Kiss Nee Szabo

Gyula Grezal

Miklos Abermann

Andras Bilkei Gorzo

Erzsebet Kaufmanne Bojti

Miléna Bea Lengyel

Judit Dredán

István Nándor Antal

Péter Szegó

Laszlo Koncz

Judit Szego

Gyongyi Vereczkey Nee Donath

Péter Hajnal

Magdolna Gora Nee Hernyes

Péter SzegÖ

Nikolett KÁLLAI

Bernadett Stiedl

Dorottya Kiss

Gabor Orgovan

Béla Noszal

The invention concerns a pH-dependent gradual sustained release composition for increasing the pH in the upper part of the small intestines. Particles of the composition are provided with a multilayer polymer coating of specific structure which ensures the gradual release of the active agent in the range of pH 4.5 to 5.5. A process for preparing said composition is also claimed.

pH-dependent gradual release pharmaceutical composition

1,7,7-trimethyl-bicyclo[2.2.1]heptane derivatives as anxiolytic agents

The invention relates to oral solid pharmaceutical composition containing as active ingredient gemfibrozil and conventional pharmaceutical auxiliary agents comprising as surfactant bis-(2-ethyl-hexyl)-sodium-sulfosuccinate in an amount of 0.05-0.5% by weight relative to gemfibrozil content of the composition. The pharmaceutical compositions according to the present invention contain a relatively small amount of a surfactant, provide uniform dissolution of the active ingredient among the different batches and the standard deviation of the dissolution rate is low.

Gemfibrozil containing pharmaceutical compositions

The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing a one-layer tablet core including a polymeric film-coat, a therapeutically active agent and a hydrophilic polymer; if desired, a two-layer tablet core including active agent and hydrophilic polymer in the first layer thereof and a hydrophilic polymer in the second layer thereof; at least one bore on the part of film-coat in contact with the core or core layer containing the active agent; and, if desired, containing one or more bore(s) in the part thereof in contact with the second layer containing the hydrophilic polymer, which comprises an ammonium methacrylate copolymer as coating material and hydroxypropyl-methylcellulose as hydrophilic polymer. The composition according to the invention is useful for preparing controlled drug-release tablets containing as active agents e.g. .beta.-adrenergic inhibitors (e.g. propranolol) calcium-antagonists (e.g. nifedipine), angiotensin convertase enzyme (ACE) inhibitors (e.g. captopril); prazosin; or nitroglycerol, all used in heart and circulation diseases; vasodilatory active agents (e.g. pentoxyfylline), nonsteroidal antiinflammatory agents (e.g. naproxene), analgetic drugs (e.g. morphine) and drugs acting on the central nervous system (e.g. amitriptyline, buspiron). The invention furthermore relates to a process for the preparation of the above compositions.

Diffusion-osmotic controlled drug-release pharmaceutical composition and

Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.

Process for the preparation of high purity buspiron and the

The invention relates to fodder additives comprising a compound inducing the microsomal enzyme system of the liver, preferably a compound of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are identical or different and stand for hydrogen, halogen, trihalomethyl, or alkyl or alkoxy each containing from 1 to 6 carbon atoms;

Fodder additive and a process for the preparation

The invention relates to new dialkylaminoalkoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;

Dialkylaminoalkoxybenzylalcohol derivatives, process for their

The invention relates to new aminopropanol derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkoxy having from one to 3 carbon atoms or alkyl having from one to 3 carbon atoms,

1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation

The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,

Diethylaminoalkoxybenzhydrol derivatives, process for their preparation

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

Process for the preparation of 3-trifluoromethyl-and

The invention relates to new resorcin derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 3 carbon atoms or alkoxy having from one to 3 carbon atoms. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

Resorcin derivatives, process for their preparation and pharmaceutical

The invention relates to new 4-hydroxy-benzhydrols of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, with the proviso that if R.sub.1 is hydrogen, R.sub.2 is other than hydrogen or a 3-trifluoromethyl group, or if R.sub.1 is a 2-methyl group, R.sub.2 is other than a 5-methyl group. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredients are also within the scope of the invention.

4-Hydroxy-benzhydrols, process for their preparation and pharmaceutical

Growing community of inventors

Budapest, Hungary

Imre Klebovich