Merrion Research III Limited

Elan Corporation, Plc

Cytogen Corporation

Merrion Research I Limited

Other

Sarlan, Ltd.

Imelda Lambkin

Daniel Joseph O'Mahony

Richard Allen Houghten

Vernon L Alvarez

Clemencia Pinilla

Benjamin A Belinka, Jr

Gerard M Cagney

Catherine A Patterson

Judith Singleton

John M Carter

Lisa Higgins

Christa Hamashin

Amy Schink

Lisa Osthues-Spindler

Richard Houghten

Daniel O'MAHONY

Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.

Conjugates of membrane translocating agents and pharmaceutically active agents

Purified synthetic polypeptide ligands for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithelial tissue, especially Peyer's patch and/or M-Cell tissue. Also methods of using the ligands.

Peyer's patch and/or M-cell targeting ligands

The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to a MTLP-active agent complex and a MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.

Membrane translocating peptide drug delivery system

UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.

Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

Purified synthetic polypeptide ligands comprising a 12-mer L-peptide, D-peptides being the D-form of the 12-mer L-peptides, 12-mer retro-inverted peptides being the retro-inverted form of the 12-mer L-peptide, or fragments and homologues thereof, are disclosed. These ligands are for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithelial tissue, especially Peyer's patch and/or M-Cell tissue. Methods of using the ligands are also disclosed.

Growing community of inventors

Sutton, Ireland

Imelda Lambkin