Universitéde Montreal

Fred Hutchinson Cancer Center

British Columbia Cancer Agency Branch

Iman Fares

Guy Sauvageau

Stéphane Gingras

Yves Gareau

Jalila Chagraoui

Rejean Ruel

Hans-Peter Kiem

Réjean Ruel

Keith Richard Humphries

It is provided a method of expanding ex vivo hematopoietic stem cells (HSC), the method comprising selecting a population of Endothelial Protein C Receptor (EPCR)HSC, culturing the selected HSC thereby expanding said EPCRHSC and the use of the expanded EPCRHSC for stem cells transplantation.

Selection of human hematopoetic stem cells using EPCR

Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.

Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.

Compounds and methods for enhancing viral gene transfer to human hematopoietic cells

Growing community of inventors

Montréal, Canada

Iman Fares