Codexis, Inc.

Iman Farasat

Jovana Nazor

Da Duan

Agustina Rodriguez-Granillo

Oscar Alvizo

Anna Fryszkowska

Nicholas M Marshall

Jeffrey C Moore

Vesna Mitchell

Jonathan Vroom

Nikki Dellas

Jack S Liang

James Nicholas Riggins

Mark A Huffman

Deeptak Verma

Grant S Murphy

Harvinder Chagger Maniar

Jonathan S Penfield

Santhosh Sivaramakrishnan

Joshua N Kolev

Hao Yang

Christopher Michael Micklitsch

Rama Voladri

Paul N Devine

Birgit Kosjek

Keith Allen Canada

Stephan Jenne

Robert Kevin Orr

Katrina W Lexa

Auric Anthony Sowell-Kantz

Judy Victoria Antonio Viduya

Chihui An

Steven Miller

The present invention provides engineered transaminase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered transaminase polypeptides. Methods for producing transaminase enzymes are also provided. In some embodiments, the engineered transaminase polypeptides are optimized to provide improved enzyme properties under minimal aqueous conditions in wet organic solvents.

Engineered transaminase polypeptides

The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.

Engineered deoxyribose-phosphate aldolases

The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Ketoreductase polypeptides and polynucleotides

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Penicillin-g acylases

Growing community of inventors

Rahway, NJ, United States of America

Iman Farasat