National Guard Health Affairs

King Saud Bin Abdulaziz University for Health Sciences

King Abdullah International Medical Research Center

King Abdullah Inetrnational Medical Research Center

Imadul Islam

Mohamed Boudjelal

Atef Nehdi

Rabih Omran Al-Kaysi

Rizwan Ali

Ahmed Alaskar

Bandar Alghanem

Hajar Mohammed Alzahrani

Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.

Anticancer 1,3-dioxane-4,6-dione derivatives and method of combinatorial synthesis thereof

The present disclosure relates to methods of reducing the number of abnormal PBMC cells in a leukemia patient. The methods may include administering an effective amount of a drug, which may not be indicated for leukemia, or an antibody-drug conjugate. The antibody-drug conjugate includes an antibody selected from the group consisting of an anti-&#x3b1;-adrenoreceptor antibody, an anti-&#x3b2; adrenoceptor antibody, an anti-trace amine-associated receptor 1 antibody, an anti-dopamine receptor antibody, and an anti-serotonin receptor antibody; a drug selected from the group consisting of isoproterenol, methyldopa, olanzapine, and a derivative thereof; and a linker that conjugates the antibody and the drug.

Method for treating leukemia

Growing community of inventors

Riyadh, Saudi Arabia

Imadul Islam