Protalix Ltd.

Ilya Ruderfer

Avidor Shulman

Yoseph Shaaltiel

Tali Kizhner

Talia Shekhter

Yaniv Azulay

Tehila Ben-Moshe

Liat Fux

Lilach Chen Zeltsburg

Yulia Ugortsev

Hagit Neta

Sivan Gelley

Elad Lavee Laviad

Tehila Ben Moshe

Orit Shilovittzky

Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

Stabilized alpha-galactosidase and uses thereof

Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.

Modified DNase and uses thereof

Stabilized &#x3b1;-galactosidase and uses thereof

Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

Saccharide-containing protein conjugates and uses thereof

Growing community of inventors

Carmiel, Israel

Ilya Ruderfer